Hyperemesis Gravidarum Medication: Relief for Severe Morning Sickness


Hyperemesis gravidarum (HG) is a severe form of morning sickness that affects pregnant women. It is characterized by excessive and persistent nausea and vomiting, leading to dehydration and weight loss. While lifestyle changes and supportive measures can provide some relief, medication is often necessary to manage the symptoms effectively. In this article, we will explore various hyperemesis gravidarum medications commonly used to alleviate the discomfort experienced by expectant mothers.

Hyperemesis Gravidarum Quiz

Do I have Hyperemesis Gravidarum?

Answer the following questions to find out:

Question 1:

Have you been experiencing severe nausea and vomiting during pregnancy?

Question 2:

Have you lost more than 5% of your pre-pregnancy weight due to vomiting?

Question 3:

Have you been unable to keep down any food or fluids for more than 24 hours?

Understanding Hyperemesis Gravidarum

Hyperemesis gravidarum is a condition that affects approximately 1-2% of pregnant women. Unlike typical morning sickness, which tends to subside after the first trimester, HG persists throughout pregnancy. It can cause severe dehydration, malnutrition, electrolyte imbalances, and weight loss, posing risks to both the mother and the developing fetus.

The Importance of Medication

While hyperemesis gravidarum can be physically and emotionally challenging, there are medications available to help manage the symptoms effectively. It is essential to consult with a healthcare professional to determine the appropriate medication and dosage based on the severity of the condition and individual circumstances.

Antiemetic Medications

Antiemetic medications are commonly prescribed to relieve nausea and vomiting associated with hyperemesis gravidarum. Here are three commonly used medications:

4.1 Ondansetron (Zofran)

Ondansetron, sold under the brand name Zofran, is an effective antiemetic medication frequently prescribed for hyperemesis gravidarum. It works by blocking the action of serotonin, a chemical in the body that triggers nausea and vomiting. Ondansetron can be taken orally or administered via intravenous (IV) infusion in severe cases. However, it is essential to discuss potential risks and benefits with a healthcare professional before starting this medication.

4.2 Metoclopramide (Reglan)

Metoclopramide, marketed as Reglan, is another medication commonly used to manage HG symptoms. It enhances the movement of the stomach and intestines, reducing the feeling of nausea and the frequency of vomiting. Metoclopramide can be taken orally or through an injection, providing relief for many pregnant women. However, as with any medication, it is important to discuss potential side effects and risks with a healthcare provider.

4.3 Promethazine (Phenergan)

Promethazine, known as Phenergan, is an antihistamine medication that can help alleviate nausea and vomiting associated with HG. It works by blocking the action of histamine, a substance released during an allergic reaction that can trigger these symptoms. Promethazine is available in different forms, including tablets, suppositories, and injections. As with any medication, it is crucial to consult with a healthcare professional to determine the most suitable option.


In some cases, corticosteroids may be prescribed to manage hyperemesis gravidarum. These medications help reduce inflammation and can be effective in controlling severe symptoms. Two commonly used corticosteroids for HG treatment are:

5.1 Methylprednisolone (Medrol)

Methylprednisolone, sold as Medrol, is a corticosteroid that can be administered orally or through intravenous infusion. It works by suppressing the immune system and reducing inflammation. In hyperemesis gravidarum cases where other treatments have not been effective, methylprednisolone may be considered. However, due to potential risks associated with corticosteroid use during pregnancy, careful monitoring and discussions with a healthcare provider are crucial.

5.2 Dexamethasone (Decadron)

Dexamethasone, also known as Decadron, is another corticosteroid that can be prescribed to manage severe HG symptoms. It has anti-inflammatory properties and can help reduce nausea and vomiting. Dexamethasone can be administered orally or via injection. As with any medication, potential risks and benefits should be discussed thoroughly with a healthcare professional.

Vitamin B6 (Pyridoxine)

Vitamin B6, also known as pyridoxine, is a natural remedy that can provide relief from mild to moderate hyperemesis gravidarum symptoms. It can be taken orally or through intravenous infusion, depending on the severity of the condition. Vitamin B6 is often recommended as an initial treatment option due to its low risk of side effects. However, it may not be sufficient for severe cases and should be used under the guidance of a healthcare provider.


Ginger has long been used as a natural remedy for nausea and vomiting. It can be consumed in various forms, including fresh ginger, ginger tea, or ginger supplements. While there is limited scientific evidence to support its effectiveness specifically for hyperemesis gravidarum, many pregnant women find ginger helpful in reducing their symptoms. It is important to consult with a healthcare professional before incorporating ginger into your treatment plan.

Dietary and Lifestyle Modifications

In addition to medication, certain dietary and lifestyle modifications can help manage hyperemesis gravidarum symptoms. It is essential to:

  • Eat small, frequent meals to prevent an empty stomach.
  • Avoid spicy, greasy, or strong-smelling foods that may trigger nausea.
  • Stay hydrated by drinking fluids regularly.
  • Get plenty of rest and take breaks when needed.
  • Consider relaxation techniques, such as deep breathing or prenatal yoga, to reduce stress.

Alternative Therapies

While medications play a crucial role in managing hyperemesis gravidarum, some women may seek alternative therapies for additional relief. Acupuncture, acupressure wristbands, and hypnosis are among the alternative therapies that some pregnant women find helpful. However, it is important to consult with a qualified healthcare provider before incorporating these therapies to ensure they are safe and appropriate for your specific situation.


Hyperemesis gravidarum can significantly impact the well-being of pregnant women, but effective relief is available. Medications such as ondansetron, metoclopramide, and promethazine can help alleviate severe nausea and vomiting. Corticosteroids like methylprednisolone and dexamethasone may be considered in certain cases. Natural remedies like vitamin B6 and ginger, along with dietary and lifestyle modifications, can also provide relief. However, it is crucial to consult with ahealthcare professional to determine the most suitable treatment options for your individual needs.


Is hyperemesis gravidarum harmful to the baby?

Hyperemesis gravidarum can pose risks to both the mother and the developing fetus due to dehydration and malnutrition. Seeking medical attention and appropriate treatment is crucial to ensure the well-being of both.

Can I take over-the-counter medications for hyperemesis gravidarum?

It is important to consult with a healthcare professional before taking any over-the-counter medications during pregnancy. They can provide guidance on the safety and effectiveness of specific medications.

Are there any home remedies for hyperemesis gravidarum?

While there are no guaranteed home remedies for hyperemesis gravidarum, some women find relief through ginger, vitamin B6 supplements, and dietary modifications. However, it is advisable to discuss these options with a healthcare provider.

When should I seek medical help for hyperemesis gravidarum?

It is recommended to seek medical help if you experience severe and persistent nausea and vomiting, are unable to keep any fluids down, or notice signs of dehydration such as dizziness or dark urine.

Can hyperemesis gravidarum recur in future pregnancies?

Hyperemesis gravidarum can recur in subsequent pregnancies, but it is not always the case. Each pregnancy is unique, and the severity of symptoms may vary. Consulting with a healthcare professional can help manage the condition effectively in future pregnancies.

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